Endocrine Abstracts

Background: In 2019, funding for continuous glucose monitoring (CGM) commenced for children and young people with diabetes (CYPD) in our region. However, there was no local established CGM structured education programme. We developed ‘the CGM Academy’ with continuous improvement using the Plan-Do-Study-Act (PDSA) cycle.Objectives: To review the PDSA cycle of improvements to deliver structured education using CGM.Methods: ...

Background: Continuous Glucose Monitoring (CGM) is now becoming the standard of care for children and young people with diabetes (CYPD). Due to a lack of validated education programmes, we created ‘The CGM Academy’ delivering evidence-based structured education. The results of the first 50 CYPD graduating from the academy demonstrated statistically significant improvement in time in range (TIR, 3.9-10.0 mmol/l) by 8.3% (P<0.001) and HbA1c by 3.8 mmol/mol...

Peer Review programmes (PRP) help organisations to improve the quality of clinical services in a developmental and supportive way. The West Midlands Paediatric diabetes network (WMPDN) consists of 15 National Health Service (NHS) Trusts looking after 2800 children (aged 0–18 years). 2010/2011 National Paediatric diabetes audit (NPDA) data showed that the median HBA1c achieved in the region was 69 mmol/mol. In order to improve the metabolic control and quality of care, the...

Background: PHPT is often overlooked/underdiagnosed. Several strategies (biochemical markers alone or combined in complex algorithms) have been investigated to easily diagnose/screen PHPT, but PHPT diagnosis remains challenging at present, especially in asymptomatic patients. As serum calcium (Ca) and phosphorous (P) are inversely related in PHPT, the Ca/P ratio could be a good candidate tool for PHPT diagnosis. Surprisingly, no literature data on Ca/P ratio are available, des...

Background: The diagnosis of PHPT and chronic HypoPT is still challenging, mainly due to the wide spectrum of clinical and biochemical presentation and the lack of validated diagnostic index in literature. The serum Ca/P ratio has been proposed as an accurate tool to diagnose PHPT in a small sample of patients, while no data is available about its possible application for HypoPT.Aim: To validate the serum Ca/P ratio as a diagnostic index for PHPT and to ...

Background: Primary hyperparathyroidism (HyperPT) and primary hypoparathyroidism (HypoPT) are often underdiagnosed. Several strategies have been investigated in the past in order to identify diagnostic parameters, although the diagnosis of both HyperPT and HypoPT remains challenging so far, especially in asymptomatic patients. Calcium (Ca) and phosphorus (P) are inversely related together, thus the Ca/P ratio could be an useful tool to define these conditions. Recently, we pro...

This study aims to recruit 22,000 women in early gestation to screen for thyroid failure. The trial is randomised such that half the women are being tested in early gestation (group1) while the remainder (group 2) are tested after delivery. As T4 is important for the developing foetal brain, the IQ of the children from group 1, whose mothers will have been treated with T4, is expected to be higher than that from group 2.Women are entered on the basis of ...

Background: Thyroid hormones participate in maturation, differentiation and triggering of immunity, but little is known about the modulating role of thyroid hormones on intracellular enzymatic reactions of immune cells and their role in immunopathogenesis of Graves’ disease (GD).Methods: The activity of NAD(P)-dependent dehydrogenases in lymphocytes and neutrophils ofperipheral blood was studied in a group of 145 women with GD, 53 (36.5%) pati...

Introduction: Evaluation of glucocorticoid production generally requires a dynamic test. Cut-off levels for baseline cortisol concentrations predicting the outcome of a Synacthen test have been proposed for different cortisol assays. With introduction of the new Roche Elecsys Cortisol II assay, P-cortisol concentrations are expected to decrease by 20%. We have investigated cut-off levels for baseline P-cortisol concentrations measured with the Roche Elecsys Cortisol II assay t...

Early events in activated by adrenaline (10−6 M) and phenylephrine (10−5M) single hepatocytes of rat have been investigated by quantitative image microfluorometry and microspectrofluorometry. Membrane potential-sensitive cationic DiOC2(3) and anionic SqSC4 probes have been used for image analysis and transmenbrane potential (Δψp) estimation in real-time studies. Fluorescence spectra resulting from the accumulati...